The $5.6M lesson in escalation protocol failure every physician should read

By Alpana Mohta, MD, DNB, FEADV, FIADVL, IFAADFact-checked by Barbara BekieszPublished November 10, 2025


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In cases of limb-threatening ischemia or wounds, physicians should escalate care if pulse is absent in the limb, the skin is cool and mottled, there is pain with rest, loss of sensation, delayed cap refill of more than three seconds, or if wounds not healing despite proper wound care.

—Pamela Tambini, MD

A June 2025 verdict awarded $5.6 million to a patient whose limb was amputated following alleged failures of escalation at Samaritan Medical Center in Watertown, NY. []

In limb-threatening situations, not having a defined escalation protocol can lead to catastrophic patient harm and huge institutional liability. []

The bulk of lawsuits stem from either diagnostic delay (e.g., undetected infection, clot, critical limb ischemia) or failure of postoperative monitoring/management (e.g., wound necrosis, compartment syndrome, vascular compromise).

In many claims, plaintiffs must show that standard of care was breached, and prove causation linking that breach to the limb loss, as well as indicating lifelong damages. []

In the case above, while full details are not publicly disclosed, the outsized award suggests the court accepted that escalation gaps materially contributed to the harm.

From a patient-safety perspective, a missed opportunity to salvage a limb may arise from fragmented care, delayed recognition, or absence of clear thresholds to escalate consultations (vascular, interventional, surgical, wound care). 

Discussion among a panel of experts emphasized the need for a multidisciplinary care coordinator or liaison nurse to track high-risk patients and trigger escalations when clinical markers cross thresholds. []

Related: 8 outrageous malpractice cases—and what physicians can learn from them

What does the literature tell us?

Even when amputation seems likely, shared decision-making and timely reassessment are critical. Yet “surgeon paternalism” often prevails. []

A report on chronic limb-threatening ischemia argues that early communication about “amputation risk” helps patients mentally prepare and enables structured planning of escalation or salvage pathways. []

However, orthopedic guidelines from the AAOS note that limb salvage decisions are not static: If complications develop (e.g., infection, nonhealing, vascular insufficiency), clinicians should revisit amputation vs salvage. []

What makes a reliable escalation plan?

A shared decision framework in trauma/amputation contexts has been advocated in the recent literature. []

One vascular center that implemented a limb salvage program (LSP) reported a drop in amputation rates from 29% to 1% over five years, aided by rigorous protocols for when to escalate care. []

According to Alok Mohta, MD, a board-certified physician, certain patients should be flagged in the EMR as part of risk stratification, specifically, patients with diabetic foot ulcer, PAD/CLI, recent revascularization, or chronic wounds. Predefined metrics (e.g., limb perfusion indices, lactate, wound enlargement, imaging findings) should prompt triggers.

Pamela Tambini, MD, medical director at Engage Wellness, elaborated further:  “In cases of limb-threatening ischemia or wounds, physicians should escalate care if pulse is absent in the limb, the skin is cool and mottled, there is pain with rest, loss of sensation, delayed cap refill of more than three seconds, or if wounds not healing despite proper wound care. Also, ankle-brachial index or toe pressure can be measured to assess limb heath, where an ankle-brachial index <0.4 or toe pressure <30 mmHg requires urgent vascular assessment and intervention.”

Guarav Parmar, MD, MPH, a vascular medicine specialist at Massachusetts General Hospital and one of the limb-salvage panel of experts, said: “We have a multidisciplinary team…and are trying to have the liaison nurse help coordinate care for all patients at risk for amputation.” []

Related: Family awarded $951 million in Utah's largest malpractice verdict ever

Barriers and challenges

As noted in the AAOS guidelines, predicting which limbs are salvageable is inherently uncertain. Scoring systems exist but lack perfect validity. []

In resource-limited settings, access to interventional radiology or vascular surgery may lag behind decision points. In addition, clinician inertia and siloed specialty domains can also delay uptake of central escalation systems.

Finally, some patients resist amputation discussions emotionally. These are hard conversations to have, and they can sometimes get deferred under pressure of time.

Related: A surgeon let her 12-year-old 'assist' in brain surgery—now, she's facing a malpractice suit

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