Influence of prucalopride on esophageal secondary peristalsis in reflux patients with ineffective motility

Journal of Gastroenterology and Hepatology | September 13, 2017

Lei WY, et al. - This study was conducted to ascertain whether prucalopride would augment secondary peristalsis in gastroesophageal reflux disease (GERD) patients with ineffective esophageal motility (IEM). In IEM patients, prucalopride enhanced primary peristalsis as well as mechanosensitivity of secondary peristalsis with limited effect on secondary peristaltic activities. The authors proposed that in patients with IEM, prucalopride appeared to be useful in augmenting secondary peristalsis only via sensory modulation of esophageal secondary peristalsis.

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