Migraine and hypercoagulable states in ischemic stroke

CephalalgiaMartinezSanchez P et al. – | November 23, 2011

In young patients with ischemic stroke, migraine may be associated with a higher frequency of hypercoagulable states (HS).


  • This was a prospective study of patients under 55 years of age with brain ischemia.
  • A systematic questionnaire addressed the antecedent of migraine with aura (MA) or without aura (MO).
  • Authors investigated the presence of HS by an extensive battery of haematological tests.
  • The presence of patent foramen ovale (PFO) was assessed by trans–oesophageal echocardiography.


  • A total of 154 patients (95 men; mean ± SD age, 44.12 ± 8.4 years) were included; 44 had migraine, 15 had MA.
  • HS were more frequent in the migraine than non–migraine group (38.6% vs. 16.4%, p < 0.01).
  • The multivariate analysis showed that MO was associated with a 2.88–fold (95% CI, 1.14 to 7.28) increased risk of HS diagnosis.
  • However, in the group of patients with brain infarction under 50 years old, MA, but not MO, was independently associated with HS (OR 6.81; 95% CI, 1.01 to 45.79).

Read the full article on Cephalalgia