The results of this clinical observation further elaborated the efficacy and safety of SR oxycodone tablets in the treatment of moderate to severe painful diabetic peripheral neuropathy in China.
- This was a multicenter, randomized, open–labeled study.
- This study was completed in 12 hospitals in China.
- A total of 80 Chinese patients undergoing moderate to severe painful DPN.
- An initial dose of 10 mg is recommended to be taken orally every 12 hours.
- Dose titration was done appropriately according to pain intensity and adverse reactions.
- Data record included days, dosage, analgesic efficacy, quality of sleep, adverse events, and combination therapy when patients were treated with SR oxycodone tablets.
- The continuous observation period was 6 weeks.
- After medication for 1 week, pain was significantly (P < 0.01) relieved from 6.8 ± 1.4 to 2.8 ± 1.6.
- Onset time was within 45 minutes in nearly 60% of the patients, and within 1 hour in nearly 95% of that ones.
- More than 90% of the patients achieved stable analgesic dose within 3 days.
- After using SR oxycodone tablets for 1 week, sleep quality was significantly (P < 0.01) improved.
- In week 1, the average dose of SR oxycodone tablets was 16.63 ± 7.79 mg.
- The average daily dose of most patients was about 20 mg after 2 weeks.
- In all the enrolled patients, 38 (47.5%) had adverse reactions.
- No serious adverse reactions took place.
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