Associations between cerebral and systemic endothelial function in migraine patients: a post-hoc study

BMC Neurology | November 17, 2011

Perko D et al. – This study suggests that the endothelial function in the cerebral and systemic circulation might be different in migraine patients without comorbidities, while that of the anterior and posterior cerebral circulation might be coupled. These results could improve understanding of endothelial function in migraine patients without comorbidities.


  • Cerebral and systemic endothelial function through post–hoc linear regression analysis of cerebrovascular reactivity (CVR) to L–arginine between the middle cerebral artery (MCA) and flow–mediated vasodilatation (FMD) of the right brachial artery and the posterior cerebral artery (PCA) and FMD in migraine patients without comorbidities and in healthy subjects
  • Anterior and posterior cerebral endothelial function was also compared using post–hoc linear regression analysis between CVR to L–arginine in the MCA and the PCA.


  • No significant correlation was found between CVR to L–arginine in the MCA and FMD and in the PCA and FMD in migraine patients with aura (p=0.880 vs. p=0.682), without aura (p=0.153 vs. p=0.179) and in healthy subjects (p=0.869 vs. p=0.662).
  • On the other hand, the authors found a significant correlation between CVR to L–arginine in the MCA and PCA in migraine patients with aura (p=0.004), without aura (p=0.001) and in healthy subjects (p=0.002).
  • Detailed analysis of the linear regression between all migraine patients and healthy subjects did not show any difference in the regression coefficient (slope) (p=0.382).
  • However, a significant difference in curve elevation (intercept) was found (p=0.002).

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