Short-term vitamin D3 supplementation in children with neurodisabilities: Comparison of two delivery methods

Hormone Research in Paediatrics | September 14, 2017

Penagini F, et al. - The physicians conducted this work to compare adequacy of vitamin D3 buccal spray with that of oral drops. The results suggested that vitamin D3 supplementation with buccal spray and oral drops are equally effective in short-term treatment of vitamin D deficiency in children with neurodisabilities. Importantly, buccal spray may be more acceptable by the patients.


  • Researchers randomly assigned 24 children with neurodisabilities (5–17 years) and vitamin D deficiency (25(OH)D ≤20 ng/mL) to receive vitamin D3 buccal spray 800 IU/daily (n = 12) or oral drops 750 IU/daily (n = 12) for 3 months during winter.


  • It was noted that both groups had a significant increase in 25(OH)D (z = 150; p < 0.0001).
  • In both groups, the differences between baseline and final parathyroid hormone measurements did not reach significance.
  • They observed that markers of bone formation and resorption did not change significantly in both groups.
  • The data indicated that the satisfaction with the formulation was significantly higher in the patients using spray.

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