As atopic dermatitis (AD) is complicated by an elevated risk for skin and systemic infections, researchers conducted this review to update the pathophysiology, diagnosis, management, controversy of antibiotic use, and potential treatments of infectious complications of AD. From PubMed database searches and clinical pictures, they obtained studies relevant to the mechanisms, diagnosis, management, and potential therapy of infectious complications of AD. Findings revealed infectious complications as a comorbidity of AD. Following were identified as the major predisposing factors for the increased infections in AD: skin barrier defects, type 2 inflammation, Staphylococcus aureus colonization, and cutaneous dysbiosis. Although systemic bacterial infections and eczema herpeticum are not common, these can be life-threatening. In AD, preventive therapy of infections stresses skin barrier improvement and anti-inflammatory therapy.
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