The impact of caffeine consumption on clinical symptoms in patients with bipolar disorder: A systematic review

By Frigerio S, Strawbridge R, Young AH.
Published September 29, 2020

Key Takeaways

Researchers aimed at ascertaining if caffeine intake/withdrawal influences the natural course of bipolar disorder (BD), in terms of clinical outcomes, by examining all literature reporting on this topic. PubMed, Embase and PsycINFO were searched up to July 17, 2020 and a total of 1,678 records were reviewed; 17 studies met inclusion criteria (10 case reports, 1 retrospective cohort study, 5 cross‐sectional studies, 1 interventional study). The literature identified is, however, not conclusive. Overall, the findings suggest there may be some correlation between the quantities of caffeine that individuals with BD consume and the severity of symptoms experienced. In patients with BD, acute increases in caffeine consumption may precede the occurrence of manic symptoms, possibly via a direct stimulant effect, influencing sleep patterns; the metabolism of lithium or other medications may also be impacted, although higher caffeine intake could also be due to an ongoing manic relapse or a prodromal sign.

Read the full article on Bipolar Disorders.

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