Systolic blood pressure postural changes variability is associated with greater dementia risk

By Rouch L, Vidal JS, Hoang T, et al.
Published October 5, 2020

Key Takeaways

By analyzing 2,131 older adults from the Health, Aging, and Body Composition cohort study, researchers investigated if orthostatic hypotension (OHYPO) and visit-to-visit blood pressure (BP) postural alterations variability are related to incident dementia. During a 5-year baseline span of time, orthostatic BP was examined repeatedly. Using various indicators, such as SD and coefficient of variation, BP postural changes variability over time was assessed. A greater dementia risk was observed in relation to systolic OHYPO and visit-to-visit systolic BP (SBP) postural changes variability. These data give rise to the question of potential prophylactic interventions to control orthostatic SBP as well as its fluctuations.

Read the full article on Neurology.

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