Risk of pregnancy loss prior to 20 weeks gestation with COVID-19

By Jacoby VL, Murtha A, Afshar Y, et al
Published June 24, 2021

Key Takeaways

Researchers sought to report the outcomes of a cohort of US women with SARS-CoV-2 infection in early pregnancy. An ongoing nationwide prospective cohort study of COVID-19 during pregnancy, named PRIORITY, involved 1,338 participants. The analysis set comprised 109 of these participants who were enrolled at < 14 weeks gestation; 94 were COVID-19 positive, 15 were COVID-19 negative. In this nationwide study of pregnant people in the US, participants with COVID-19 and COVID-19 negative controls, both, showed the risk of pregnancy loss of about 6% at < 20 weeks gestation. Among clinically identified first trimester pregnancies prior to the pandemic, this data compares favorably to the 10% rate of miscarriage. This study is identified to be the largest analyses of COVID-19 in the first trimester in a US longitudinal cohort. With this sample size, the upper bound of the confidence interval for pregnancy loss of 13.4% is reassuring as it is not significantly greater than the expected miscarriage rate without viral infection. In guidance of these results, people infected with SARS-CoV-2 early in pregnancy can be counseled.

Read the full article on American Journal of Obstetrics and Gynecology.

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