In the present study, the researchers sought to assess the Asthma Symptom Index [ASI] and replicate Asthma Symptom Utility Index (ASUI) psychometric properties, involving validity, reliability, responsiveness, and minimal clinically important difference estimation in patients ≥12 years of age with severe asthma. Patients from a randomized trial (MUSCA [n = 497]) and a cross-sectional study (IDEAL [n = 721]) have been analyzed post hoc. Demographic information, spirometry, ASI and ASUI scores, and other patient-reported outcome measures like Asthma Control Questionnaire (ACQ-5) and St George's Respiratory Questionnaire (SGRQ) at baseline and during follow-up (MUSCA only) have been obtained. The findings show the ASI's strong reliability, validity, and responsiveness, suggesting potential value for real-world symptom assessment in severe asthma.
Read the full article on The Journal of Allergy and Clinical Immunology: In Practice.