Oral fluoroquinolones and risk of aortic or mitral regurgitation: A nationwide nested case-control study

This nested case-control study was conducted to investigate if and how oral fluoroquinolones (FQs) use is linked with incident valvular regurgitation. In this study, Danish administrative registers were used, and a nationwide cohort was analyzed. Cases were characterized as the first occurrence of aortic or mitral regurgitation. Findings showed there was no significant connection of FQ exposure with increased rates of aortic or mitral regurgitation, relative to penicillin V users. A likely causal link between FQ exposure and incident valvular regurgitation was not supported by the results of this study.