Multi-morbidity and blood pressure trajectories in hypertensive patients: A multiple landmark cohort study

By Tran J, Norton R, Canoy D, et al
Published June 17, 2021

Key Takeaways

This study was carried out to assess the burden and types of comorbidities in patients with hypertension and to assess how such comorbidities and other variables affect BP levels over time. Between 2000 and 2014, researchers designed a multiple landmark cohort study using linked electronic health records from the United Kingdom Clinical Practice Research Datalink to compare systolic blood pressure (SBP) levels in 295,487 patients (51% women) aged 61.5 (SD = 13.1) years with first recorded diagnosis of hypertension, by type and numbers of major comorbidities, from at least 5 years before and up to 10 years after hypertension diagnosis. Results imply that this early selection bias of hypertension diagnosis at different BP levels was a key determinant of long-term differences in BP by comorbidity status. The findings demonstrate that the lack of a more rapid decline in SBP in those with multi-morbidity provides some reassurance for BP treatment in these high-risk individuals.

Read the full article on PLoS Medicine.

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