Left bundle branch block is associated with a similar dyssynchronous phenotype in heart failure patients with normal and reduced ejection fractions

By Friedman DJ, Emerek K, Kisslo J, et al
Published October 22, 2020

Key Takeaways

Since few therapies improve outcomes in patients with heart failure with preserved ejection fraction (HFpEF), researchers conducted a cross-sectional analysis of selected patients with HFpEF (ejection fraction ≥ 50%) with and without left bundle branch block (LBBB) (normal conduction, NC) and patients with HFrEF and LBBB who were suitable cardiac resynchronization therapy candidates to describe and contextualize the mechanical phenotype of LBBB in HFpEF. Eighty-two patients with HFpEF (50 with NC, 32 with LBBB) and 149 patients with HFrEF (all with LBBB) meet the requirements. Compared with HFpEF patients with NC, patients with HFpEF and LBBB frequently have a LBBB dyssynchrony phenotype, prolonged isovolumetric contraction time and isovolumetric relaxation time, and reduced ejection time. The electromechanical dyssynchrony and disordered cardiac timing of HFpEF with LBBB is identical to HFrEF with LBBB.

Read the full article on American Heart Journal.

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