J-shaped association between fasting blood glucose levels and COVID-19 severity in patients without diabetes

By Zhu B, Jin S, Wu L, et al
Published August 24, 2020

Key Takeaways

In this retrospective, multi-centered study of 293 coronavirus disease 2019 (COVID-19) patients without diabetes, researchers intended to determine if there is a connection between fasting blood glucose (FBG) levels and the risk of COVID-19 disease progression, with the goal of providing clinical evidence for glycemic targets in patients. Using the multivariate stepwise binary logistic regression analysis, they tested the dose-response effects of FBG levels on the risk of the severe and critical condition in COVID-19 patients. According to results, FBG levels were plotted in quintiles with set at < 4.74, 4.74-5.21, 5.21-5.78, 5.78-7.05, and ≧7.05 mmol/L. In non-diabetes patients with COVID-19, with nadir at 4.74-5.78 mmol/L, evidence of J-shaped associations between FBG and risk of severe and critical condition was observed.

Read the full article on Diabetes Research and Clinical Practice.

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