Infections and the development of childhood acute lymphoblastic leukemia: A population-based study

By Hwee J, Sutradhar R, Kwong JC, et al
Published October 6, 2020

Key Takeaways

Using administrative databases, researchers performed a matched case-control study to assess the correlation between the rate of infections and childhood acute lymphoblastic leukemia diagnosed between the ages of 2 to 14 years from Ontario, Canada and used a validated approach to measure infections. In 1,600 cases of acute lymphoblastic leukemia, and 16,000 matched cancer-free controls aged 2–14 years, having > 2 infections/year increased the chances of childhood acute lymphoblastic leukemia by 43% compared with children with ≤ 0.25 infections/year. Having > 2 respiratory infections/year increased chances of acute lymphoblastic leukemia by 28% compared with children with ≤ 0.25 respiratory infections/year. The risk of developing childhood acute lymphoblastic leukemia increased with further infections and having an infection between the ages of 1-1.5 years increased the likelihood of childhood acute lymphoblastic leukemia.

Read the full article on European Journal of Cancer Prevention.

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