Individual response to antidepressants for depression in adults-A meta- analysis and simulation study

By Munkholm K
Published August 27, 2020

Key Takeaways

The observation that response toward antidepressants for depression differ among patients encourages the assumption that treatment can be personalized. Researchers sought to compare the outcome variance in patients receiving antidepressants vs patients receiving placebo in randomized controlled trials (RCTs) of adults with major depressive disorder (MDD). In addition, they described components of variation of RCTs using simulated data. Analysis was performed on data from 222 RCTs examining 19 different antidepressants compared with placebo in 345 comparisons; these RCTs comprised a total of 61,144 adults with an MDD diagnosis. Outcomes yielded no evidence for individual disparities in treatment effects of antidepressants for depression in adults. The data, however, do not led researchers to reject the null hypothesis of equal variances in the antidepressant group and the placebo group. As RCTs cannot give direct evidence for individual treatment effects, the findings indicate that it may be most appropriate to assume that the average effect of antidepressants relates also to the individual patient.

Read the full article on PLoS Neglected Tropical Diseases.

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