This study was attempted to evaluate the effect of intensive blood pressure control on the incidence of new-onset atrial fibrillation/flutter (AF) and the prognostic implications of preexisting and new-onset AF in Systolic Blood Pressure Intervention Trial participants. Incident rates of new-onset AF were estimated using poisson regression modeling. Researchers applied multivariable-adjusted Cox proportional hazard models to analyze the risk of adverse cardiovascular events (composite of myocardial infarction, non–myocardial infarction acute coronary syndrome, stroke, heart failure, or cardiovascular death). A total of 9,327 individuals were included in the study. The study suggests that in an older, high-risk, nondiabetic population, intensive blood pressure control does not diminish the incidence of new-onset AF. The data reveal that both preexisting and new-onset AF have adverse prognostic implications. Residual cardiovascular risk is evident even with on-treatment blood pressure < 120/80 mm Hg in participants with preexisting AF.
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