House dust endotoxin, asthma and allergic sensitization through childhood into adolescence

By Gehring U, Wijga AH, Koppelman GH, et al
Published August 15, 2020

Key Takeaways

Researchers conducted the study for analyzing the correlations of house dust endotoxin (lipopolysaccharide [LPS]), a constituent of the outer membrane of gram‐negative bacteria, with asthma and allergic sensitization from birth to age 17 years longitudinally taking into account exposure early in life and at primary school age. They utilized data of 854 candidates of the prospective Dutch PIAMA birth cohort study with house dust endotoxin measurements at 3 months and/or 5‐6 years and data on asthma and/or allergic sensitization from at least one of 11 follow‐ups until age 17. Higher living room floor dust endotoxin concentrations at 3 months were linked to lower chances of asthma up to 4 years of age, but not subsequently in children of allergic mothers. Higher living room floor dust endotoxin at 5‐6 years was related to higher odds of sensitization at 8‐16 years. House dust endotoxin in preschool children of allergic mothers can have beneficial effects on asthma which do not persist in adolescence. Beneficial correlations could not be established with allergic sensitization.

Read the full article on Clinical & Experimental Allergy.

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