This study was carried out to assess whether GSTP1 positive prostatic adenocarcinomas are more common in Black than White men in the United States. Immunohistochemistry against GSTP1 was used to analyze 1,673 primary prostatic adenocarcinomas on tissue microarrays with redundant sampling from the index tumor from prostatectomies. It has been reported that GSTP1-positive prostate cancers are substantially over-represented among prostate cancers from Black in comparison with white men. This finding should prompt additional studies to ascertain if GSTP1 positive cases represent a distinct molecular subtype of prostate cancer and if GSTP1 expression could provide a biological underpinning for the observed disparate outcomes for Black men.
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