Early pregnancy atherogenic profile in a first pregnancy and hypertension risk 2 to 7 years after delivery

Given that females with adverse pregnancy outcomes (APOs) carry elevated cardiovascular risk, but the association of other factors is not known, therefore, to address this topic, researchers undertook this study with 4,471 primiparous females to examine the association of first‐trimester atherogenic markers with risk of APO (hypertensive disorders of pregnancy, preterm birth, small for gestational age), gestational diabetes mellitus (GDM) as well as hypertension (130/80 mm Hg or antihypertensive use) 2 to 7 years post-delivery. More atherogenic characteristics were present in females with an APO/GDM (n=1102) vs those without an APO/GDM. A link with later hypertension was demonstrated by higher glucose, high‐sensitivity C‐reactive protein, and triglycerides, accounting for confounders and factors routinely evaluated antepartum. Overall, findings revealed that individual as well as integrated first‐trimester atherogenic features were related to APO/GDM occurrence and hypertension 2 to 7 years later.