Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: The Framingham heart study

By Haring R, Xanthakis V, Coviello A, et al
Published August 30, 2020

Key Takeaways

Researchers applied multilevel modelling and Generalized Estimating Equations to examine up to five serial measurements of total testosterone (TT), dehydroepiandrosterone sulphate (DHEAS), follicle-stimulating hormone, luteinizing hormone and total estradiol in older men in the original cohort of the Framingham Heart Study to determine the short‐ (2‐years; 1,165 person‐observations in 528 individuals) and long‐term (up to 10‐years follow‐up; 2520 person‐observations in 835 individuals with mean baseline age: 71.2 years) clinical correlates of these sex steroids and gonadotropins. The community‐based study distinguished modifiable correlates of reducing TT and DHEAS concentrations in elderly men, implying that maintenance of a low CVD risk factor burden may mitigate the age‐related decline of these hormones over late adulthood.

Read the full article on International Journal of Andrology.

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