Cholesterol uptake capacity: A new measure of high-density lipoprotein functionality as a predictor of subsequent revascularization in patients undergoing percutaneous coronary intervention

By Fujimoto D, Otake H, Kawamori H, et al
Published January 24, 2022

Key Takeaways

Findings demonstrate an independent association between serum cholesterol-uptake capacity (CUC; a rapid cell-free assay system that directly assesses the capacity of HDL to accept additional cholesterol) level at index percutaneous coronary intervention (PCI) and subsequent revascularization post-PCI. Subsequent revascularization after PCI might be predicted by continuously evaluating high-density lipoprotein (HDL) functionality by CUC.

  • In this retrospective review, 74 PCI patients who had subsequent revascularization and 183 patients who had follow-up coronary angiography without revascularization were included.

  • The revascularization group had significantly lower serum CUC level at the index PCI, vs the non-revascularization group (84.3 [75.2–98.9] vs 92.0 [81.6–103.3 A U.]).

  • In multivariate logistic regression analysis, reduced serum CUC level at the index PCI was shown to be independently linked with subsequent revascularization (odds ratio, 0.98).

  • In the revascularization group, serum CUC level at the index PCI and follow-up and the absolute alteration in serum CUC level from the index PCI to follow-up were significantly lower, compared with those in the non-revascularization group, post-adjusting for 16 cardiovascular risk factors.

Read the full article on Atherosclerosis.

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