Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms

By Sugranyes GM, de la Serna E, Ilzarbe D, et al
Published September 21, 2020

Key Takeaways

Considering that evaluation of child and adolescent offspring of patients with schizophrenia (SzO) or bipolar disorder (BpO) may aid in attaining insight into the changes taking place in the brain in individuals at increased risk for disease during a key developmental period, researchers performed clinical, cognitive and neuroimaging assessment of 128 individuals (33 SzO and 46 BpO, considered jointly as ‘Familial High Risk’ (FHR), and 49 controls) aged 6–17 years at baseline, 2‐ and 4‐year follow‐up. During follow‐up, psychotic spectrum symptoms developed in 20 FHR participants (11 SzO and 9 BpO) but not in 59 FHR participants. Smaller cross‐sectional surface area and progressive cortical thinning were evident in correlation with the emergence of psychotic spectrum symptoms in FHR. Relative preservation of surface area over time may indicate distinct processes based on familial risk.

Read the full article on Journal of Child Psychology and Psychiatry.

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