Blood biomarkers associated with inflammation predict poor prognosis in cerebral venous thrombosis

By de Sousa DA, Pereira‐Santos MC, Serra‐Caetano A, et al
Published September 13, 2020

Key Takeaways

Researchers ascertained if blood biomarkers of inflammation were correlated with the evolution of brain lesions, persistent venous occlusion, or functional outcome in patients with cerebral venous thrombosis (CVT). Evaluation of neutrophil‐to‐lymphocyte ratio (NLR) and C‐reactive protein (CRP) concentrations in peripheral blood samples obtained at admission in 62 individuals. Additional quantification of IL‐6 was conducted at 1, 3, and 8, in 35 patients and 22 healthy controls. At baseline, IL‐6 levels were increased in patients with CVT with a peak. IL‐6, NLR, and CRP levels were not associated with brain lesion outcomes or early recanalization but had a significant connection with the unfavorable functional outcome at 90‐days. Increased baseline levels of NLR, CRP, and IL‐6 in patients with CVT can serve as new predictive markers of worse functional prognosis at 90‐days. There was no association between inflammatory markers and early evolution of brain lesion or venous recanalization.

Read the full article on European Journal of Neurology.

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