Associations between polygenic risk score for age at menarche and menopause, reproductive timing, and serum hormone levels in multiple race/ethnic groups

By Zhao W, Smith JA, Bielak LF, et al
Published June 30, 2021

Key Takeaways

In the present study, the researchers sought to explore correlations of genetic loci that contribute to age at menarche and menopause with sentinel menopausal traits in multiple race/ethnic groups. The Study of Women's Health Across the Nation includes genetic data from 738 White, 366 Black, 139 Chinese, and 145 Japanese women aged 42 to 52 at baseline. Menopause polygenic risk score (PRS) was significantly linked to age at menopause in White women after Bonferroni correction and nominally associated in Chinese and Japanese women. Menarche PRS was significantly related to age at menarche in White and nominally associated in Black and Japanese women. In addition to menopausal timing, PRSs associated with the onset and end of reproductive life were linked to reproductive lifespan, menopausal transition length, and E2 levels in different racial/ethnic groups.

Read the full article on Menopause.

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