Association of psoriasis with incident venous thromboembolism and peripheral vascular disease

By Chen TL, Lee LL, Huang HK, et al
Published January 19, 2022

Key Takeaways

In psoriatic disease patients, there exists an increased risk for incident venous thromboembolism (VTE) and peripheral vascular disease (PVD). In psoriasis cases, typical presentations of VTE or PVD should not be overlooked. Identifying and treating risk factors such as obesity, physical inactivity, smoking, and varicose veins in patients with psoriasis, as well as exercising caution in prescribing medications like hormone-related therapies, both are recommended.

  • In this systematic review and meta-analysis of 13 cohort studies with 12,435,982 participants, the association of psoriasis with incident VTE and PVD was investigated.

  • Patients with psoriasis were found to have a significantly elevated risk for incident VTE (pooled hazard ratio HR, 1.26) and PVD (pooled HR, 1.27).

  • In subgroup analyses, an increased risk for incident VTE was present among participants with psoriatic arthritis (pooled HR, 1.24), women (pooled HR, 1.89), and those in Asia (pooled HR, 2.02) and Europe (pooled HR, 1.28).

Read the full article on JAMA.

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