This retrospective cohort study was conducted to examine if and how vascular overload index (VOI), a marker of arterial stiffness and arteriolar resistance, was associated with new-onset ischemic stroke in an elderly population with hypertension. Participants included 3315 hypertensive persons aged 60 years or more. A median follow-up of 5.5 years was performed, and 206 participants reached the endpoint, new-onset ischemic stroke. Findings demonstrated a significant link between VOI and the incidence of new-onset ischemic stroke in this population. Elevated VOI was identified as the cardiovascular risk factor and was shown to increase the likelihood of new-onset ischemic stroke.
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