Are serum cholesterol levels associated with cognitive impairment and depression in elderly individuals without dementia?: A retrospective cohort study in South Korea

By Han KT, KIM SJ.
Published August 24, 2020

Key Takeaways

Using senior cohort data from the National Health Insurance Service of South Korea, researchers investigated if serum cholesterol levels correlates with cognitive impairment and depression in older adults. Researchers recruited 128,371 participants who contributed repeated measures to this dataset. Via a self‐reported questionnaire, cognitive impairment was assessed; depression was measured using claim data. This study's findings demonstrate that HDL‐C is correlated with depressive symptoms, and could be key in prognosticating psychiatric symptoms or cognitive decline. Low‐density lipoprotein cholesterol (LDL‐C), total cholesterol (TC), or triglycerides (TG) were not significantly linked with cognitive impairment. This research implies that routine health screenings may aid in the early detection of high‐risk individuals.

Read the full article on International Journal of Geriatric Psychiatry.

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