A preliminary study on functional activation and connectivity during frustration in youths with bipolar disorder

By Ross AJ, Roule AL, Deveney CM, et al
Published August 13, 2020

Key Takeaways

Since little is known about functional activation and connectivity in the brain of bipolar disorder (BD) youths in response to frustration, researchers conducted this exploratory study to compare BD youths and healthy volunteers (HV) on attentional abilities, self‐reported affect, and functional activation and connectivity during a frustrating attention task. Twenty BD (Mage15.86) and 20 HV (Mage =15.55) youths performed an fMRI paradigm that differentiated neural responses during the processing of frustrating feedback from neural responses during attention orienting following frustrating feedback. Findings suggested no association of BD with atypical activation patterns. Positive IFG‐vmPFC connectivity and striatum‐insula decoupling in BD during feedback processing can mediate increased sensitivity to reward‐relevant stimuli. Elevated IFG‐PAG/PHG connectivity in BD following frustration may recommend more attention network recruitment to regulate arousal and to maintain goal-directed behavior.

Read the full article on Bipolar Disorders.

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