Women with kidney disease are at higher risk for peripheral artery disease than men

By John Murphy, MDLinx
Published November 12, 2015

Key Takeaways

Researchers have found that among patients with chronic kidney disease (CKD), women under age 70 had a greater risk of peripheral artery disease (PAD) than men. After age 70, women and men have about the same risk, according to researchers from the Perelman School of Medicine at the University of Pennsylvania, in Philadelphia, PA, who presented these results November 10, 2015 at the American Heart Association Scientific Sessions, held in Orlando, FL.

The researchers also showed that while older men had a substantially greater risk of PAD compared with younger men, in women the risk was greatest earlier in life, and did not increase with age.

To conduct this study, the researchers analyzed data from the Chronic Renal Insufficiency Cohort (CRIC), a multi-center, prospective study of 3,174 CKD participants. Results showed that 17.8% of participants developed PAD and 11.1% died over a median follow-up of nearly 6 years. Women had a 1.53-fold greater risk of PAD compared with men, researchers found.

“We set out to determine whether there were gender differences in peripheral artery disease in patients with CKD, and found that women had an increased risk compared to men; however, this relationship was modified by age,” said the study’s lead author, Grace Wang, MD, Assistant Professor of Surgery and Radiology, and Director of the Vascular Laboratory at the Hospital of the University of Pennsylvania.

“The analysis showed that women were more at risk for PAD early on, starting around age 40, but the risk in men became greater as they aged,” she said.

The researchers added that further studies are needed to understand the biological and clinical basis for these differences.

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