SLICC-FI predictive of future hospitalizations in systemic lupus erythematosus patients

By Samar Mahmoud, MS
Published February 24, 2022

Key Takeaways

  • This study found that the Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) was predictive of future hospitalizations among patients with systemic lupus erythematosus (SLE). 

  • This study further supports the use of SLICC-FI as a health measure in SLE patients.

The SLICC-FI has been developed as a tool to predict outcomes in SLE patients. It combines disease activity, organ damage, co-morbidities, and functional status.

Why This Study Matters 

While the SLICC-FI is a predictor of mortality and organ damage accrual in patients with SLE, its association with hospitalization has not been evaluated. This study sought to determine the association with baseline SLICC-FI values with future hospitalization in SLE patients.

Study Design 

The study included 1549 patients with SLE. Investigators calculated baseline SLICC-FI scores for each patient. During an average follow-up period of 7.2 ± 3.7 years, the number and duration of inpatient hospitalizations were recorded. Investigators used a negative binomial regression to estimate the link between baseline SLICC-FI values and the rate of hospitalizations per patient-year of follow-up. 

Results and Conclusions

The majority of participants enrolled in the study were female (88.7%) with an average age of 35.7 ± 13.3 years.  The average baseline SLICC-FI was 0.17 ± 0.08. During the follow-up period, 614 patients (39.6%) experienced 1,570 hospitalizations. Higher SLICC-FI values were associated with more frequent hospitalizations. In patients with at least 1 hospitalization, higher baseline SLICC-FI values were predictive of more hospitalization time. 

Related Research

Consider these findings from similar research studies:

  • The SLICC-FI is predictive or organ damage accrual and mortality risk in patients with established SLE (Source). 

  • In women with established SLE, higher baseline SLICC-FI scores were linked with a higher risk of damage accrual at 5-year follow-up (Source).

Original Source 

Legge A, Kirkland S, Rockwood K, et al. Prediction of hospitalizations in systemic lupus erythematosus using the systemic lupus international collaborating clinics frailty index. Arthritis Care & Research. Published online February 17, 2022:acr.24504.

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