Proton pump inhibitors accelerate vascular aging - video

By John Murphy, MDLinx
Published May 13, 2016

Key Takeaways

Long-term use of proton pump inhibitors (PPIs) can speed up the biological aging of endothelial cells in blood vessels, researchers reported. This could be the reason why PPIs have been associated with several serious vascular conditions, according to a study published online May 10, 2016 in the journal Circulation Research.

“It’s been shown now by our group and others that users of PPIs are at increased risk for dementia, heart attack, and renal failure. We now have the smoking gun that explains these observations,” said lead author John P. Cooke, MD, PhD, Professor and Chair of the Department of Cardiovascular Sciences at Houston Methodist Research Institute, in Houston, TX.

“It raises the question whether these drugs should be over-the-counter. Should they be used without medical supervision? I think not,” Dr. Cooke said.

Because Dr. Cooke’s team tested the vascular endothelial cells in vitro, further research is necessary to confirm that PPIs act in the same way in the human body.

“Long-term studies of vascular health have not been performed in people taking the proton pump inhibitors. We need to do those studies,” Dr. Cooke said. “We need to determine if the findings that we have right now really apply to our patients—to people out there in the community who are taking these drugs.”

Watch the video from Houston Methodist here.

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