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See Latest ArticlesAssessing HER2 gene amplification as a potential target for therapy in invasive urothelial bladder cancer with a standardized methodology: Results in 1005 patients
Annals of Oncology, 11/10/09
Laé M et al. – This study showed that 5.1% of invasive bladder carcinomas had a HER2 gene amplification. These findings may have clinical implications for the management of patients with HER2-positive locally advanced or metastatic bladder cancer, as they could be potential candidates for targeted therapy.
Methods- 1005 patients
- Paraffin-embedded tissues of transurethral resection or cystectomy evaluated by immunohistochemistry (IHC), using antibodies against HER2
- All samples with a 2+ or 3+ HER2 overexpression evaluated by FISH
- HER2 overexpression observed in 93 (9.2%) tumors (2+: 42 tumors and 3+: 51 tumors)
- Using FISH, all HER2 3+ tumors had gene amplification
- No amplification found in 2+ tumors
- Intratumoral heterogeneity observed in 35% of cases
- Tumors showed same heterogeneous pattern, with adjacent 3+ positive and negative areas by both IHC and FISH
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