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Nef S et al. – Particular focus is given to the in vivo role of miRNAs that has been demonstrated through the generation of Sertoli– or germ–cell specific Dicer knockouts, as well as the potential application of these findings in the treatment of human male infertility and the development of male contraceptives. It is anticipated that unraveling miRNA functions in the testis will further our understanding of the regulatory mechanisms of mammalian spermatogenesis.

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