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Why does diabetes offer protective effects against prostate cancer? The possible role of its microvascular complications
Medical Hypotheses, 11/04/09
Weiwei Z et al. – The typical histological changes of microvascular lesions are capillary basement membrane thickening, capillary occlusion and degeneration, eventually capillary dysfunction and organ ischemia. Therefore, the authors hypothesize that DM might induce local microvascular dysfunction and prostate ischemia, which prevent initiation and development of CaP. Currently, numerous studies showing effect of anti–angiogenesis therapy on CaP strongly support the hypothesis.
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