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Expression and Localization of Hypoxia Proteins in Prostate Cancer: Prognostic Implications After Radical Prostatectomy
Urology, 11/04/09
Jans J et al. – This study confirms the upregulation of proteins involved in the HIF–1? hypoxia pathway in prostate cancer cells, indicative of a hypoxic tumor state. Importantly, we report the identification of 2 novel markers, GLUT1 and prolyl–4–hydroxylases 1, with prognostic significance for patients undergoing radical prostatectomy.
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