Urology Medical News about Erectile Dysfunction Phosphodiesterase Inhibitors Hormonal Treatments

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Oral Phosphodiesterase-5 Inhibitors and Hormonal Treatments for Erectile Dysfunction: A Systematic Review and Meta-analysis
Annals of Internal Medicine, 10/21/09

Tsertsvadze A et al. – Data primarily from short–term trials (<=12 weeks) indicate that PDE–5 inhibitors were more effective than placebo in improving sexual intercourse success (69.0% vs. 35.0%). The proportion of men with improved erections was significantly greater among those treated with PDE–5 inhibitors (range, 67.0% to 89.0%) than with placebo (range, 27.0% to 35.0%). The PDE–5 inhibitors were associated with increased risk for any adverse events compared with placebo (for example, relative risk with sildenafil, 1.72). In 4 head–to–head RCTs comparing sildenafil, vardenafil, and tadalafil, improvement of ED and adverse events did not differ among treatments. Results from 15 RCTs evaluating hormonal treatment of ED were inconsistent on whether treatment improved outcomes. Evidence was insufficient regarding whether men with ED had a higher prevalence of hypogonadism than men without ED.

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Hormonal Testing and Pharmacologic Treatment of Erectile Dysfunction: A Clinical Practice Guideline From the American College of Physicians
Annals of Internal Medicine, 10/30/09 Relevance Score: 97%

Studies show Viagra, other drugs outperform hormone treatment
Internet Source, 10/21/09 Relevance Score: 96%

New Drug Udenafil for Erectile Dysfunction in US Trials
Internet Source, 11/10/09 Relevance Score: 93%

Platelet Cyclic Guanosine Monophosphate as a Biomarker of Phosphodiesterase Type 5 Inhibitor Efficacy in the Treatment of Erectile Dysfunction: A Randomized Placebo-Controlled Study
European Urology, 11/05/09 Relevance Score: 93%

Erectile Dysfunction: Treatment With Oral Medications Demonstrates Significant Improvements In Sexual Intercourse And Erectile Function
ScienceDaily, 10/20/09 Relevance Score: 93%