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Chronic peripheral hyperinsulinemia in type 1 diabetic patients after successful combined pancreas kidney transplantation does not affect ectopic lipid accumulation in skeletal muscle and liver
Diabetes, 10/28/09

Stadler M et al. – Despite fasting peripheral hyperinsulinemia because of systemic venous drainage, T1DM after PKT show similar IHCL, IMCL, insulin sensitivity and fasting EGP in comparison to non–diabetic controls. These results suggest that systemic hyperinsulinemia per se does not cause ectopic lipid accumulation in liver and skeletal muscle.


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