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See Latest ArticlesSurvival benefit from ovarian metastatectomy in colorectal cancer patients with ovarian metastasis: a retrospective analysis
Cancer Chemotherapy and Pharmacology, 10/15/09
Lee SJ et al. – The ovarian metastatectomy significantly prolonged survival in CRC patients with ovarian metastases. The potential role of an ovarian metastatectomy in the management of CRC should be prospectively studied.
Methods- Between 1996 and 2008, 83 CRC patients underwent oophorectomy
- 47 CRC patients with ovarian metastasis without resection were included in analysis
- Median age was younger (48 years) in oophorectomy group compared with historical control
- Proportion of synchronous metastasis higher in oophorectomy group than in control group
- After a median follow-up duration of 60.8 months median OS significantly longer in oophorectomy group
- For ovary-specific survival (date of ovarian metastasis diagnosis to death), CRC patients with oophorectomy showed significantly more favorable survival rate than control group
- In univariate analyses, oophorectomy , unilaterality of ovarian metastasis , metastasis confined to ovaries , normal CEA level , good performance status , palliative chemotherapy (P = 0.001), and primary disease resection identified as significantly good prognostic factors for overall survival
- Oophorectomy, chemotherapy, metastasis confined to ovaries, normal CEA level, and good performance status retained statistical significance at multivariate level
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