Urology Medical News about Prostatic Neoplasms GnRH-agonist Histrelin

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Relationships between FSH, inhibin B, anti-Mullerian hormone and testosterone during long-term treatment with the GnRH-agonist Histrelin in patients with prostate cancer
European Journal of Endocrinology, 10/30/09

Eldar–Geva T et al. – The secondary increase in FSH following initial suppression with the implant is probably related to impaired inhibin B secretion. The lack of inhibin B response to the secondary increase in FSH suggests that long–term exposure of Sertoli–cells to GnRH–agonist impairs their function. This effect appears to be selective since unlike inhibin B, AMH increased. In the absence of testosterone, FSH has a role in AMH regulation.

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