Urology Medical News

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. 2008 Exclusive Survey—Earnings: Good news for primary care income

3. Medicare pay-for-reporting effort draws fire from frustrated doctors

4. Debunking Myths in the US Healthcare System

5. Doctors and the DEA Free full text

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Association between plasma total cholesterol concentration and incident prostate cancer in the CLUE II cohort
Cancer Causes and Control, 10/13/09

Mondulet AM et al. –This study supports two prior ones suggesting that cholesterol influences risk of high-grade prostate cancer, and indirectly supports the hypothesis that cholesterol-lowering is a mechanism by which statins are protective.

Methods

Prospective study
6,816 male county residents aged 35+ years old who did not have cancer diagnosis at baseline in 1989
Plasma cholesterol, measured enzymatically at baseline categorized by clinical cutpoints
Cox proportional hazards regression used to estimate multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total (n = 438) and high-grade (Gleason sum ≥ 7, n = 137) prostate cancer

Results

Compared to men with high cholesterol (≥ 240 mg/dl), men with desirable (< 200 mg/dl) or borderline (200 to < 240 mg/dl) levels were less likely to develop high-grade prostate cancer, particularly when restricting to organ-confined cases and among men with higher BMI
Results unchanged after excluding cholesterol-lowering drug users
Cholesterol not associated with total prostate cancer

<< Previous
Testicular function after treatment for acute lymphoblastic...

Next >>
Prostate-Specific Antigen Velocity for Early Detection of...