Urology Medical News about AKT1 mutations

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AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K
Oncogene, 10/08/09

Askham JM et al. – The phosphatidylinositol–3–kinase (PI3 kinase)–AKT pathway is frequently activated in cancer. Recent reports have identified a transforming mutation of AKT1 in breast, colorectal, ovarian and lung cancers. Enhanced activation of AKT1 when E17K and E49K mutations are in tandem suggests that they can co–operate.

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Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma
The Journal of Pathology, 10/16/09 Relevance Score: 48%

Genetic Testing for Long-QT Syndrome. Distinguishing Pathogenic Mutations From Benign Variants
Circulation, 10/23/09 Relevance Score: 47%

Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers
Journal of Clinical Oncology, 10/29/09 Relevance Score: 46%

MEFV mutations in Egyptian patients suffering from familial Mediterranean fever: analysis of 12 gene mutations
Rheumatology International, 10/16/09 Relevance Score: 46%

Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer
Cancer Epidemiology, Biomarkers & Prevention, 10/05/09 Relevance Score: 46%