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Aberrant Planar Cell Polarity Induced By Urinary Tract Obstruction
American Journal of Physiology: Renal Physiology, 10/01/09
Li L et al. – The results indicate that aberrant PCP may contribute to cyst–like tubular dilatation in obstructive uropathy. Interestingly, the orientation of cell division, localization of aPKC, and Frizzled3 expression return to normal when obstruction is relieved, which suggest a role of normal planar cell polarity signaling in tubular repair.
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