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Van Meel TD et al. – Intravesical oxybutynin blocks the bladder–cooling reflex and increases but does not block CPT sensation in the bladder in most patients with incomplete neurogenic lesion and detrusor overactivity. These results help explain the clinical effect of intravesical oxybutynin in neurogenic patients. They also indicate that a pharmacological local influence on C–fiber–related activity can give different clinical effects.


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