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The effect of intravesical oxybutynin on the ice water test and on electrical perception thresholds in patients with neurogenic detrusor overactivity
Neurourology and Urodynamics, 09/30/09
Van Meel TD et al. – Intravesical oxybutynin blocks the bladder–cooling reflex and increases but does not block CPT sensation in the bladder in most patients with incomplete neurogenic lesion and detrusor overactivity. These results help explain the clinical effect of intravesical oxybutynin in neurogenic patients. They also indicate that a pharmacological local influence on C–fiber–related activity can give different clinical effects.
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