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Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy (ADT): impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis
The Prostate, 09/22/09
Isahaya E et al. – Despite the unaffected GH and upregulated bone resorption, the serum IGF–1 level was elevated by ADT. The IGF–1 level was correlated with BMD before ADT, but the relationship was disrupted after ADT. IGF–1 or its receptor in the bone may be functionally inactivated during ADT.
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