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Chiou WF et al. – Decreased expression of certain proteins that mediate the relaxant mechanism, associated with increased expression of certain proteins that mediate contractile mechanisms, might be important in the development of T2D–associated ED. In particular, down–regulated eNOS/nNOS/PKG1 as well as up–regulated ETAR/RhoA/ROCK1 might participate in the aetiology of ED in T2D.

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