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See Latest ArticlesProhibitin regulates TGF-[beta] induced apoptosis as a downstream effector of smad-dependent and -independent signaling
The Prostate, 09/03/09
Zhu B et al. – The results demonstrate that TGF–beta led to upregulation of the PKC inhibitor 14–3–3 protein and promoted its association with PHB, while PHB association with PKC–delta, was inhibited by the MEK1 inhibitor, documenting a critical interdependence between the MEK–ERK signaling and prohibitin phosphorylation. These findings suggest a dual role for PHB as a downstream determinant of the cellular response to TGF–beta via Smad–dependent pathway (apoptosis) and MAPK intracellular signaling (survival).
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