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Phase II, Randomized, Placebo-Controlled Trial of Neoadjuvant Celecoxib in Men With Clinically Localized Prostate Cancer: Evaluation of Drug-Specific Biomarkers
Journal of Clinical Oncology, 09/04/09
Antonarakis ES et al. – Treatment with 4 to 6 weeks of celecoxib had no effect on intermediate biomarkers of prostate carcinogenesis, despite the achievement of measurable tissue levels. The authors caution against using celecoxib 400 mg twice daily as a preventive agent for prostate cancer in additional studies.
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