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Waldinger MD et al. – ReGS is highly associated with pelvic varices and with sensory neuropathy of the pudendal nerve and DNC, whose symptoms are suggestive for small fiber neuropathy (SFN). Physical examination for static mechanical Hyperesthesia is a diagnostic test for ReGS and is recommended for all individuals with complaints of persistent restless genital arousal in absence of sexual desire.

Exclusive Author Commentary
Marcel D. Waldinger, MD, PhD, 09/14/09

Restless Genital Syndrome (ReGS) is characterized by persistent unwanted restless genital sensations (dysesthesias) and imminent or spontaneous orgasms combined with either Restless Legs Syndrome (RLS) and/or Overactive Bladder Syndrome (OAB) and/or urethra hypersensitivity. Although persistent unwanted genital sensations have previously been described under the term persistent genital arousal disorder (PGAD), its association with RLS and OAB has only recently been discovered (Waldinger et al, J Sex Medicine 2009; 6: 474-81 and 482-97). In the current study in 23 Dutch women with ReGS, it has been shown that the key feature of ReGS is a small fiber sensory neuropathy (SFSN) of the dorsal nerve of the clitoris (DNC) which is the distal branch of the pudendal nerve. Examination with a cotton swab in all women showed various spots of hyperesthesia in the pudendal dermatome. Finger touch of the DNC along the ramus inferior of the pubic bone (RIPB) provoked ReGS in all women. The findings of the current study show that ReGS is no longer a mysterious disorder.

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